ODCs

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8 OMIM references -
6 associated genes
12 signs/symptoms

PROTEIN INTERACTIONS: 2

1 OMIM reference -
1 associated gene
13 signs/symptoms

Familial melanoma

Hereditary sensory and autonomic neuropathy with spastic paraplegia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CDK4 TERT	(0.63) (0.63)	CCT5 CCT5

Citations in the biomedical literature:

Familial melanoma		Hereditary sensory and autonomic neuropathy with spastic paraplegia
	Synonym(s): (no synonyms)		Synonym(s): - HSAN with spastic paraplegia

	Classification (Orphanet): - Rare eye disease - Rare genetic disease - Rare oncologic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal recessive

	External references: 8 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Familial melanoma		Hereditary sensory and autonomic neuropathy with spastic paraplegia
	Very frequent - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Melanoma Frequent - Anomalies of the lymphatic system - Dry / squaly skin / exfoliation - Excessive freckling - Hair and scalp anomalies Occasional - Autosomal dominant inheritance - Breast neoplasm / tumor / carcinoma / cancer - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Extrapyramidal syndrome - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Retinopathy		Very frequent - Abnormal gait - Auto-aggressivity / auto-mutilation - Autosomal recessive inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Dysautonomia / autonomous nervous sytem anomalies - Hemiplegia / diplegia / hemiparesia / limb palsy - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Insensitivity to pain - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Peripheral neuropathy Frequent - Nerve conduction abnormality Occasional - Osteomyelitis / osteitis / periostitis / spondylodisciitis